ANTIMICROBIAL RESISTANCE PROFILES OF UROPATHOGENS AND THEIR IMPLICATIONS FOR EMPIRICAL TREATMENT OF URINARY TRACT INFECTIONS

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Published: Sep 1, 2026
DOI: https://doi.org/10.69980/as.v12i2.6802
Keywords:
antimicrobial resistance, urinary tract infection, uropathogens, antimicrobial susceptibility, empirical therapy

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Dr. Neha Rathore
MD Microbiology, MPMSU Jabalpur (M.P.)

Abstract

Antimicrobial resistance among uropathogens increasingly compromises empirical treatment of urinary tract infections and necessitates locally informed therapeutic strategies. This study characterized antimicrobial resistance profiles of Gram-negative uropathogens and evaluated their implications for empirical treatment. Secondary microbiological data were analyzed for 604 Gram-negative isolates, comprising Escherichia coli, Klebsiella spp., Pseudomonas spp., and Proteus spp. Susceptibility to seven antimicrobial agents was evaluated, alongside organism- and clinical-setting-specific resistance patterns and cumulative resistance burden. Escherichia coli was the predominant uropathogen (56.1%), followed by Klebsiella spp. (36.8%). Meropenem demonstrated the highest susceptibility (86.8%) and lowest resistance (10.6%), whereas amoxicillin-clavulanate showed the highest resistance (69.5%). Klebsiella spp. exhibited significantly greater resistance than E. coli to ciprofloxacin (41.9% vs. 31.3%) and meropenem (14.0% vs. 7.4%), with both differences remaining significant after false discovery rate correction (adjusted p=0.033). Overall, 43.2% of isolates were resistant to at least three of six universally tested agents. Clinical-setting differences did not remain significant after multiple-testing correction. These findings demonstrate substantial resistance heterogeneity among uropathogens and support routine local surveillance, culture-guided therapy, and antimicrobial stewardship to improve empirical UTI treatment while preserving effective antimicrobial options.

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How to Cite
Dr. Neha Rathore. (2026). ANTIMICROBIAL RESISTANCE PROFILES OF UROPATHOGENS AND THEIR IMPLICATIONS FOR EMPIRICAL TREATMENT OF URINARY TRACT INFECTIONS. IJRDO-Journal of Applied Science, 12(2), 90-99. https://doi.org/10.69980/as.v12i2.6802
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Vol. 12 No. 2 (2026): IJRDO -Journal of Applied Science (ISSN: 2455-6653)
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Articles
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